Rumen protected lysine may boost uterine health

“The increasing availability of lysine in the gut during the transition improved several indicators of uterine health,”found the team, which included Phil Cardoso, associate professor of animal sciences at the University of Illinois, Urbana-Champaign.

The study was published in Journal of Dairy Science.

Feeding rumen-protected methionine as an essential amino acid source has been shown to improve reproductive performance in dairy cows, but the effect of feeding rumen-protected lysine (RPL) during the peripartum period on reproductive performance is not well understood, according to the paper.

The authors said they wanted to determine the effects of feeding RPL before birth, after birth, or both, on follicular dynamics, uterine health and endometrial mRNA gene expression.

Uterine infections are common in the postpartum period and can adversely affect ovarian and uterine function, the authors noted.

Improving immune function and reducing the risk of inflammatory diseases of the reproductive tract could lead to better reproductive outcomes, they said.

“Uterine infections may also adversely affect ovarian resumption because inflammation can impair the growth and function of the first dominant follicle (DF) through neuroendocrine mechanisms of inhibition of hypothalamic GnRH release and pituitary LH secretion.

“In addition, there is also evidence of directly localized inflammatory mediators resulting from bacterial contamination of the uterus after calving that affect the ovaries by suppressing estradiol secretion and reducing the growth rate of follicles.

“In addition, chronic inflammation can lead to disruption of uterine regeneration processes in the early postpartum period, potentially altering uterine function and future reproductive capacity.

“Hence, ovarian resumption could benefit from modulation of the uterine immune response through nutritional strategies.”

However, the effects of feeding RPL on reproductive tract physiology and immune response are still lacking, the study states.

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